Genetic and pharmacological inactivation of the purinergic P 2 RX 7 receptor 2 dampens inflammation but increases tumor incidence in a mouse model of 3 colitis - associated cancer 4 5
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1 Genetic and pharmacological inactivation of the purinergic P2RX7 receptor 2 dampens inflammation but increases tumor incidence in a mouse model of 3 colitis-associated cancer 4 5 Paul Hofman, Julien Cherfils-Vicini, Marie Bazin, Marius Ilie, Thierry Juhel, 6 Xavier Hébuterne, Eric Gilson, Annie Schmid-Alliana, Olivier Boyer, Sahil 7 Adriouch and Valérie Vouret-Craviari # 8 9 1: Institute for Research on Cancer and Aging, Nice, France; IRCAN U1081 UMR CNRS 7284 10 2: University of Nice-Sophia Antipolis, Nice, France; 11 3: Laboratory of Clinical and Experimental Pathology and Biobank, Pasteur Hospital, Nice, France 12 4: Laboratory of Gastroenterology, Archet II Hospital, Nice, France 13 5: iBV, UMR7277 CNRS UMR1091 INSERM, Nice, France 14 6: INSERM U905, Rouen, France 15 7: Normandy University, Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France 16 8: Department of Medical Genetics, Archet 2 Hospital, CHU of Nice 17 9: Centre Antoine Lacassagne, Nice, France 18 19 Corresponding Author: Mailing address: IRCAN, Inserm U1081, UMR 7284 CNRS/Université 20 Nice-Sophia Antipolis, 28 Avenue de Valombrose, 06108 Nice, France. Phone: (33)492 031 21 223. Fax: (33)492 031 2 41. E-mail: [email protected] 22 23 Short title: P2RX7 in colitis and colon cancer 24
منابع مشابه
Genetic and pharmacological inactivation of the purinergic P2RX7 receptor dampens inflammation but increases tumor incidence in a mouse model of colitis-associated cancer.
Colitis-associated cancer (CAC) is a complication of inflammatory bowel disease (IBD). Binding of extracellular ATP to the purinergic receptor P2RX7 has emerged as a critical event in controlling intestinal inflammation, acting to limit elevation of proinflammatory mast cells and cytokines and promote survival of regulatory T cells (Treg) and enteric neurons. In this study, we investigated the ...
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تاریخ انتشار 2014